TGIF1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for TGIF1 抗体 (N-Term) (ABIN5534745)
抗原
See all TGIF1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 81-109, N-Term
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- For WB starting dilution is: 1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))
-
别名
- TGIF1
-
背景
- The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
-
分子量
- 43 kDa
-
基因ID
- 7050
-
UniProt
- Q15583
-
途径
- Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation
抗原
-