TAO Kinase 1 (TAOK1) (AA 620-650) 抗体
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Quick Overview for TAO Kinase 1 (TAOK1) (AA 620-650) 抗体 (ABIN5532220)
抗原
See all TAO Kinase 1 (TAOK1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 620-650
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
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免疫原
- This TAOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 620-650 amino acids from the Central region of human TAOK1.
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亚型
- Ig Fraction
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anti-TAO Kinase 1 (TAOK1) (AA 892-1001) antibody
TAOK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4E12 unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 400-659) antibodyTAOK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (C-Term) antibodyTAOK1 适用: 人, 大鼠, 小鼠, 猴, Cow, 犬, 马, Pig, 非洲爪蟾, Bat, Hamster, 兔, 小鸡 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) antibodyTAOK1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2320 unconjugated Recombinant Antibody
anti-TAO Kinase 1 (TAOK1) (Internal Region) antibodyTAOK1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 431-480) antibodyTAOK1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (C-Term) antibodyTAOK1 适用: 人, 大鼠, 小鼠, 猴, 非洲爪蟾 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (Internal Region) antibodyTAOK1 适用: 人, 猴 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- For WB starting dilution is: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 2 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TAO Kinase 1 (TAOK1)
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别名
- TAOK1
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背景
- TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis.
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分子量
- 116 kDa
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基因ID
- 57551
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UniProt
- Q7L7X3
抗原
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