PRDM6 抗体 (N-Term)
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北京 101111
Quick Overview for PRDM6 抗体 (N-Term) (ABIN5531881)
抗原
See all PRDM6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 44-72, N-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.
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亚型
- Ig Fraction
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anti-PR Domain Containing 6 (PRDM6) (AA 376-595) antibody
PRDM6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PR Domain Containing 6 (PRDM6) (AA 448-477) antibodyPRDM6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PR Domain Containing 6 (PRDM6) (N-Term) antibodyPRDM6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- For WB starting dilution is: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.35 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PRDM6 (PR Domain Containing 6 (PRDM6))
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别名
- PRDM6
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背景
- Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).
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分子量
- 64 kDa
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基因ID
- 93166
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UniProt
- Q9NQX0
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途径
- Regulation of Muscle Cell Differentiation
抗原
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