GCAP1 抗体 (C-Term)
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Quick Overview for GCAP1 抗体 (C-Term) (ABIN5531246)
抗原
See all GCAP1 (GUCA1A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 160-191, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
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免疫原
- This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
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亚型
- Ig Fraction
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anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 1-93) antibody
GUCA1A 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) antibodyGUCA1A 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 36-85) antibodyGUCA1A 适用: 人, 小鼠, 大鼠, 犬, 马, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
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别名
- GCAP1
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背景
- Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
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分子量
- 23 kDa
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基因ID
- 2978
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UniProt
- P43080
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
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