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VCAM1 抗体 (AA 25-270)

Name: VCAM1 抗体 (AA 25-270)
SKU: ABIN5519072
Availability: OutOfStock

VCAM1 适用: 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of VCAM1 using anti-VCAM1 antibody . (VCAM1 抗体 (AA 25-270))

IHC analysis of VCAM1 using anti-VCAM1 antibody . (VCAM1 抗体 (AA 25-270))

IHC

3 images

(7 references)

产品编号 ABIN5519072

发货至: 中国

Datasheet as PDF

抗原 See all VCAM1 抗体

VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
抗原表位
11

9

8

6

6

6

4

4

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 25-270
适用
122

90

39

18

9

8

7

6

4
小鼠, 大鼠
宿主
104

91

34

9

1

1
兔
Compatible Secondaries
克隆类型
151

87

1
多克隆
标记
139

29

27

9

7

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This VCAM1 antibody is un-conjugated
应用范围
135

109

86

82

71

37

30

16

15

8

7

6

6

5

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA

原理

Anti-VCAM1 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-VCAM1 Antibody Picoband® (ABIN5519072). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E. coli-derived mouse VCAM1 recombinant protein (Position: F25-L270).

亚型

IgG

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VCAM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 1-739) antibody
VCAM1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) antibody
VCAM1 适用: 人, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3H10 unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 25-183) antibody
VCAM1 适用: 人, 大鼠, 猴 WB, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 6A11D8 unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 109-318) antibody
VCAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 300-400) antibody
VCAM1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) antibody
VCAM1 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6G9 unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 511-682) antibody
VCAM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 369-658) antibody
VCAM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 409-682) antibody
VCAM1 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 3-2# unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA (Cap), 1-5 μg/mL
1. Cybulsky, M., Fries, J. W., Williams, A. J., Sultan, P., Eddy, R. L., Byers, M. G., Shows, T. B., Gimbrone, M. A., Jr., Collins, T. The human VCAM1 gene is assigned to chromosome 1p31-p32. (Abstract)Cytogenet. Cell Genet. 58: 1852, 1991. 2. Kumar, A. G., Dai, X. Y., Kozak, C. A., Mims, M. P., Gotto, A. M., Ballantyne, C. M. Murine VCAM-1: molecular cloning, mapping, and analysis of a truncated form. J. Immun. 153: 4088-4098, 1994. 3. Taylor, J. G., VI, Tang, D. C., Savage, S. A., Leitman, S. F., Heller, S. I., Serjeant, G. R., Rodgers, G. P., Chanock, S. J. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Blood 100: 4303-4309, 2002.

说明

We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Ma, Pan, Ren, Guo, Guo, Wei, Zheng, Chen: "15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 137, (2018) (PubMed).

Wang, Qing, Liu, Liu, Qiao, Cui, He, Zhao, Liu, Yan, Wang, Liang, Guo, Shen, Hou, Chen: "Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 188, (2018) (PubMed).

Hoffman, Adeli: "LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis." in: EBioMedicine, Vol. 28, pp. 17-18, (2018) (PubMed).

Tian, Tao, Zhao, Tai, Liu, Liu: "Isolation and morphological characterization of ovine amniotic fluid mesenchymal stem cells." in: Experimental animals, Vol. 65, Issue 2, pp. 125-34, (2017) (PubMed).

Ma, Pan, Chen, Guo, Zhao, Zheng, Chen: "Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion." in: Bioscience reports, Vol. 37, Issue 2, (2017) (PubMed).

Chen, Zhang, Chen, Liu, Wang, Zhou, Qiu, Zhang, Teng, Mao, Liu, Wei, Li: "Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis." in: Annals of dermatology, Vol. 27, Issue 2, pp. 121-7, (2015) (PubMed).

Yu, Ge, Summers, Li, Liu, Ma, Kaminski, Zhuang: "TSP-1 secreted by bone marrow stromal cells contributes to retinal ganglion cell neurite outgrowth and survival." in: PLoS ONE, Vol. 3, Issue 6, pp. e2470, (2008) (PubMed).
抗原

VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

别名

Vcam1 (VCAM1 产品)

背景

Synonyms: Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, CD106, Vcam1, Vcam-1,
Tissue Specificity: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
Background: CD106 (cluster of differentiation 106) also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. This gene is mapped to chromosome 1 by Southern analysis of somatic cell hybrids. VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated.

分子量

110 kDa

基因ID

22329

UniProt

P29533

途径

Carbohydrate Homeostasis