PON1 抗体 (AA 30-274)
Quick Overview for PON1 抗体 (AA 30-274) (ABIN5519053)
抗原
See all PON1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-274
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原理
- Anti-PON1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PON1 Antibody Picoband® (ABIN5519053). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived mouse PON1 recombinant protein (Position: A30-D274).
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亚型
- IgG
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anti-Paraoxonase 1 (PON1) (AA 20-155) antibody
PON1 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4G8D3 unconjugated
anti-Paraoxonase 1 (PON1) (AA 20-155) antibodyPON1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 4G8A12 unconjugated
anti-Paraoxonase 1 (PON1) antibodyPON1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Paraoxonase 1 (PON1) (AA 2-186) antibodyPON1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Paraoxonase 1 (PON1) antibodyPON1 适用: 人, 猴 WB, FACS 宿主: 小鼠 Monoclonal 2A9 unconjugated
anti-Paraoxonase 1 (PON1) (AA 35-206) antibodyPON1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Paraoxonase 1 (PON1) (AA 187-354) antibodyPON1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Paraoxonase 1 (PON1) (AA 2-355) antibodyPON1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Paraoxonase 1 (PON1) antibodyPON1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Paraoxonase 1 (PON1) (AA 246-355) antibodyPON1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H7 unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Western blot, 0.1-0.5 μg/mL
1. Costa LG, Cole TB, Vitalone A, Furlong CE (2005). "Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity". CLINICA CHEMICA ACTA 352 (1-2): 37-47. 2. Khateeb J, Gantman A, Kreitenberg AJ, Aviram M, Fuhrman B (January 2010). "Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway".Atherosclerosis 208 (1): 119-25. 3. Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics 33 (3): 498-507. -
说明
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We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PON1 (Paraoxonase 1 (PON1))
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别名
- Pon1
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背景
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Synonyms: Serum paraoxonase/arylesterase 1, PON 1, 3.1.1.2
Tissue Specificity: Plasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL.
Background: Serum paraoxonase/arylesterase 1 (PON1), also known as aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. It is mapped to 7q21.3. This gene has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.
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分子量
- 43 kDa
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基因ID
- 18979
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UniProt
- P52430
抗原
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