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OTC 抗体 (N-Term)

This anti-OTC antibody is a 兔 多克隆 antibody detecting OTC in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN5518860
发货至: 中国

Quick Overview for OTC 抗体 (N-Term) (ABIN5518860)

抗原

See all OTC 抗体
OTC (Ornithine Carbamoyltransferase (OTC))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This OTC antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 33-70, N-Term

    原理

    Anti-Ornithine Carbamoyltransferase/OTC Antibody Picoband®

    序列

    NKVQLKGRDL LTLKNFTGEE IKYMLWLSAD LKFRIKQK

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-Ornithine Carbamoyltransferase/OTC Antibody Picoband® (ABIN5518860). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the N-terminus of human OTC, different from the related mouse and rat sequences by three amino acids.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
    1. Langley DB, Templeton MD, Fields BA, Mitchell RE, Collyer CA (June 2000). "Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism". J. Biol. Chem. 275 (26): 20012-9. 2. Nagamine T, Saito S, Kaneko M, Sekiguchi T, Sugimoto H, Takehara K, Takagi H (June 1995). "Effect of biotin on ammonia intoxication in rats and mice". J. Gastroenterol. 30 (3): 351-5.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    OTC (Ornithine Carbamoyltransferase (OTC))

    别名

    OTC

    背景

    Synonyms: Ornithine carbamoyltransferase, mitochondrial,2.1.3.3,Ornithine transcarbamylase,OTCase,OTC,

    Tissue Specificity: Mainly expressed in liver and intestinal mucosa.

    Background: Ornithine transcarbamylase (OTC) (also called ornithine carbamoyltransferase) is an enzyme that catalyzes the reaction between carbamoyl phosphate (CP) and ornithine (Orn) to form citrulline (Cit) and phosphate (Pi). This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may also play a role in that disease.

    分子量

    40 kDa

    基因ID

    5009

    UniProt

    P00480
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