CYP2D6 抗体 (C-Term)
Quick Overview for CYP2D6 抗体 (C-Term) (ABIN5518823)
抗原
See all CYP2D6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 315-347, C-Term
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原理
- Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband®
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序列
- AWGLLLMILH PDVQRRVQQE IDDVIGQVRR PEM
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Cytochrome 2D6/CYP2D6 Antibody Picoband® (ABIN5518823). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Cytochrome P450 2D6.
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亚型
- IgG
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anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 236-472) antibody
CYP2D6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) antibodyCYP2D6 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 268-457) antibodyCYP2D6 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 315-347) antibodyCYP2D6 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 1-497) antibodyCYP2D6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 91-190) antibodyCYP2D6 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2C5 unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 101-150) antibodyCYP2D6 适用: 人, 猴, 绵羊, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 20-230) antibodyCYP2D6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (N-Term) antibodyCYP2D6 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) (AA 101-210) antibodyCYP2D6 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
1.""Entrez Gene: CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6". 2. Distlerath, L. M., Guengerich, F. P.Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.Proc. Nat. Acad. Sci.81: 7348-7352, 1984. 3. Gonzalez, F. J., Matsunaga, T., Nagata, K., Meyer, U. A., Nebert, D. W., Pastewka, J., Kozak, C. A., Gillette, J., Gelboin, H. V., Hardwick, J. P.Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.DNA6: 149-161, 1987. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))
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别名
- CYP2D6
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背景
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Synonyms: Cytochrome P450 2D6,1.14.14.1,CYPIID6,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase,CYP2D6,CYP2DL1,
Tissue Specificity: Widely expressed in hematopoietic cells. Expressed in neutrophils. Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells.
Background: Cytochrome P450 2D6 (CYP2D6) is one of the most important enzymes involved in the metabolism of xenobiotics in the body. It is a member of Cytochrome P450, family 2, subfamily D, polypeptide 6. This gene is mapped to chromosome 22q13.1. It has got 497 amino acid proteins which shares 73 % sequence identity with the rat protein. CYP2D6 is highly expressed in human liver and it is the major isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus syndrome observed with procainamide.
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分子量
- 56 kDa
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基因ID
- 1565
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UniProt
- P10635
抗原
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