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CD147 抗体 (AA 138-323)

Name: CD147 抗体 (AA 138-323)
SKU: ABIN5518743
Availability: OutOfStock

BSG 适用: 人 WB, FACS, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

IHC analysis of CD147/Emmprin using anti-CD147/Emmprin antibody . (CD147 抗体 (AA 138-323))

IHC

Western blot analysis of CD147/Emmprin using anti-CD147/Emmprin antibody . (CD147 抗体 (AA 138-323))

IHC

Flow Cytometry analysis of A549 cells using anti-CD147/Emmprin antibody . (CD147 抗体 (AA 138-323))

FACS

Flow Cytometry analysis of Hela cells using anti-CD147/Emmprin antibody . (CD147 抗体 (AA 138-323))

FACS

IHC

9 images

(3 references)

产品编号 ABIN5518743

发货至: 中国

Datasheet as PDF

抗原 See all CD147 (BSG) 抗体

CD147 (BSG) (Basigin (Ok Blood Group) (BSG))
抗原表位
15

9

7

7

5

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 138-323
适用
140

45

36

16

3

3

2

2

1

1

1
人
宿主
81

71

6

1
兔
Compatible Secondaries
克隆类型
91

63

4
多克隆
标记
84

10

10

8

4

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD147 antibody is un-conjugated
应用范围
84

81

41

40

36

20

14

13

12

12

10

9

8

3

2

2

2

2

2

2

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

原理

Anti-CD147/Emmprin/BSG Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-/Emmprin/BSG Antibody Picoband® (ABIN5518743). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human CD147/Emmprin recombinant protein (Position: E138-A323). Human CD147/Emmprin shares 51.1% and 51.9% amino acid (aa) sequence identity with mouse and rat CD147/Emmprin, respectively.

亚型

IgG

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anti-Basigin (Ok Blood Group) (BSG) (N-Term) antibody
BSG 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Immunofluorescence, 2 μg/mL, Human
Flow Cytometry, 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Guo, H., Majmudar, G., Jensen, T. C., Biswas, C., Toole, B. P., Gordon, M. K.Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.Gene 220: 99-108, 1998. 2. Zhou, S., Zhou, H., Walian, P. J., Jap, B. K.CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Zhang, Yang, Liu, Liu, Teng, Zhang, Yin, Liu et al.: "iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of ..." in: Oncology letters, Vol. 14, Issue 3, pp. 3734-3740, (2017) (PubMed).

Xiao, Zhao, Shen, Liang, Chen: "Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma." in: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 2637-2642, (2017) (PubMed).

Lu, Lv, Kim, Ha, Kim: "Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma." in: Oncology letters, Vol. 5, Issue 1, pp. 201-207, (2012) (PubMed).
抗原

CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

别名

BSG (BSG 产品)

背景

Synonyms: Basigin,5F7,Collagenase stimulatory factor,Extracellular matrix metalloproteinase inducer,EMMPRIN,Leukocyte activation antigen M6,OK blood group antigen,Tumor cell-derived collagenase stimulatory factor,TCSF,CD147,BSG,UNQ6505/PRO21383,
Tissue Specificity: Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Background: Emmprin, extracellular matrix metalloproteinase inducer, also known as Emmprin (BSG) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the Emmprin gene. The human BSG gene is mapped to 19p13.3. This protein is a determinant for the Ok blood group system. BSG has been shown to be an essential receptor on red blood cells for the malaria parasite. It is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily, it plays fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development. BSG is thought also to play a role in intercellular recognition. It also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. BSG is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes.

分子量

38-55 kDa

基因ID

682

UniProt

P35613

途径

S100 Proteins