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DISC1 抗体 (Middle Region)

This anti-DISC1 antibody is a 兔 多克隆 antibody detecting DISC1 in WB 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN5518699
发货至: 中国

Quick Overview for DISC1 抗体 (Middle Region) (ABIN5518699)

抗原

See all DISC1 抗体
DISC1 (Disrupted in Schizophrenia 1 (DISC1))

适用

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  • 15
  • 1
人, 小鼠, 大鼠

宿主

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  • 4
  • 1
  • 1

克隆类型

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  • 7
多克隆

标记

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  • 2
  • 2
  • 1
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  • 1
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This DISC1 antibody is un-conjugated

应用范围

  • 45
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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 15
    • 7
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    • 6
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    • 4
    • 2
    • 2
    • 2
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    • 2
    • 2
    • 1
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    AA 461-477, Middle Region

    原理

    Anti-DISC1 Antibody Picoband®

    序列

    EKQQLQKEIE ALQARMF

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-DISC1 Antibody (ABIN5518699). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence in the middle region of human DISC1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Ma, L., Liu, Y., Ky, B., Shughrue, P. J., Austin, C. P., Morris, J. A. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (disrupted-in-schizophrenia 1). Genomics 80: 662-672, 2002. 2. Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., Thomson, P. A., Hill, E. V., Brandon, N. J., Rain, J.-C., Camargo, L. M., Whiting, P. J., Houslay, M. D., Blackwood, D. H. R., Muir, W. J., Porteous, D. J. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310: 1187-1191, 2005. 3. Ozeki, Y., Tomoda, T., Kleiderlein, J., Kamiya, A., Bord, L., Fujii, K., Okawa, M., Yamada, N., Hatten, M. E., Snyder, S. H., Ross, C. A., Sawa, A. Disrupted-in-schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc. Nat. Acad. Sci. 100: 289-294, 2003.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Sodium azide, Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    DISC1 (Disrupted in Schizophrenia 1 (DISC1))

    别名

    DISC1

    背景

    Synonyms: Disrupted in schizophrenia 1 protein,DISC1,KIAA0457,

    Tissue Specificity: Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. .

    Background: DISC1 (Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al. (2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al. (2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al. (2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.

    Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

    分子量

    94 kDa

    途径

    Regulation of Cell Size
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