DISC1 抗体 (Middle Region)
Quick Overview for DISC1 抗体 (Middle Region) (ABIN5518699)
抗原
See all DISC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 461-477, Middle Region
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原理
- Anti-DISC1 Antibody Picoband®
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序列
- EKQQLQKEIE ALQARMF
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-DISC1 Antibody (ABIN5518699). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human DISC1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.
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亚型
- IgG
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anti-Disrupted in Schizophrenia 1 (DISC1) (AA 102-261) antibody
DISC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) antibodyDISC1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 1-200) antibodyDISC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 99-325) antibodyDISC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 151-330) antibodyDISC1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 700-728), (C-Term) antibodyDISC1 适用: 人 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 101-200) antibodyDISC1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 761-832) antibodyDISC1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (N-Term) antibodyDISC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (Internal Region) antibodyVerified DISC1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Ma, L., Liu, Y., Ky, B., Shughrue, P. J., Austin, C. P., Morris, J. A. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (disrupted-in-schizophrenia 1). Genomics 80: 662-672, 2002. 2. Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., Thomson, P. A., Hill, E. V., Brandon, N. J., Rain, J.-C., Camargo, L. M., Whiting, P. J., Houslay, M. D., Blackwood, D. H. R., Muir, W. J., Porteous, D. J. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310: 1187-1191, 2005. 3. Ozeki, Y., Tomoda, T., Kleiderlein, J., Kamiya, A., Bord, L., Fujii, K., Okawa, M., Yamada, N., Hatten, M. E., Snyder, S. H., Ross, C. A., Sawa, A. Disrupted-in-schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc. Nat. Acad. Sci. 100: 289-294, 2003. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- DISC1 (Disrupted in Schizophrenia 1 (DISC1))
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别名
- DISC1
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背景
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Synonyms: Disrupted in schizophrenia 1 protein,DISC1,KIAA0457,
Tissue Specificity: Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. .
Background: DISC1 (Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al. (2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al. (2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al. (2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
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分子量
- 94 kDa
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途径
- Regulation of Cell Size
抗原
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