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CCM2 抗体 (N-Term)

This anti-CCM2 antibody is a 兔 多克隆 antibody detecting CCM2 in WB. Suitable for 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 和 斑马鱼.
产品编号 ABIN5515477
发货至: 中国

Quick Overview for CCM2 抗体 (N-Term) (ABIN5515477)

抗原

See all CCM2 抗体
CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

适用

人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼

宿主

  • 17
  • 7
  • 1

克隆类型

  • 21
  • 4
多克隆

标记

  • 18
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CCM2 antibody is un-conjugated

应用范围

  • 16
  • 6
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • 抗原表位

    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term

    序列

    EFHTGYSMEN EPGIVSPFKR VFLKGEKSRD KKAHEKVTER RPLHTVVLSL

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

    产品特性

    This is a rabbit polyclonal antibody against CCM2. It was validated on Western Blot.

    纯化方法

    Affinity purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N-terminal region of Human CCM2
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

    别名

    CCM2

    背景

    This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

    Alias Symbols: C7orf22, PP10187

    Protein Interaction Partner: SRPK2, SMURF2, SMURF1, POT1,

    Protein Size: 465

    基因ID

    83605

    途径

    Cell-Cell Junction Organization
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