ROBO3 抗体 (C-Term)
Quick Overview for ROBO3 抗体 (C-Term) (ABIN5515113)
抗原
See all ROBO3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- HPSRSPSAQE PRGSCCPSNP DPDDRYYNEA GISLYLAQTA RGTAAPGEGP
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产品特性
- This is a rabbit polyclonal antibody against ROBO3. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human ROBO3
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anti-Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3) (AA 1-147) antibody
ROBO3 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2H1 unconjugated
anti-Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3) (AA 1237-1386) antibodyROBO3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3) (Internal Region) antibodyVerified ROBO3 适用: 人 ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3) (AA 1-147) antibodyROBO3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3) (AA 1-147) antibodyROBO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
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别名
- ROBO3
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背景
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This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Alias Symbols: ROBO3,
Protein Interaction Partner: CCDC57, LNX1, RBMX, MTUS2, Zswim8, APOA1, NEDD4L, UBC,
Protein Size: 1386 -
基因ID
- 64221
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NCBI登录号
- NP_071765
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UniProt
- Q96MS0
抗原
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