NANOS2 抗体 (C-Term)
Quick Overview for NANOS2 抗体 (C-Term) (ABIN5514981)
抗原
See all NANOS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- TPDGVVVCPI LRHYVCPVCG ATGDQAHTLK YCPLNGGQQS LYRRSGRNSA
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预测反应
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against NANOS2. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human NANOS2
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anti-Nanos Homolog 2 (NANOS2) (AA 1-138) antibody
NANOS2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nanos Homolog 2 (NANOS2) (AA 1-138) antibodyNANOS2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nanos Homolog 2 (NANOS2) (AA 108-137), (C-Term) antibodyNANOS2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13985-13986 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NANOS2 (Nanos Homolog 2 (NANOS2))
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别名
- NANOS2
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背景
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NANOS2 plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. It represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. It maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. It regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. It is required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.
Alias Symbols: NANOS2, NOS2,
Protein Interaction Partner: CCNDBP1, MAGEA12,
Protein Size: 138 -
基因ID
- 339345
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NCBI登录号
- NP_001025032
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UniProt
- P60321
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途径
- Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
抗原
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