PNP 抗体 (Middle Region)
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北京 101111
Quick Overview for PNP 抗体 (Middle Region) (ABIN5514791)
抗原
See all PNP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- PNP Antibody - middle region
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序列
- IMLIRDHINL PGFSGQNPLR GPNDERFGDR FPAMSDAYDR TMRQRALSTW
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产品特性
- This is a rabbit polyclonal antibody against PNPH. It was validated on Western Blot.
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of Human PNPH
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75005-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- PNP (Purine Nucleoside Phosphorylase (PNP))
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别名
- PNP
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背景
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Background Information: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Gene Name: purine nucleoside phosphorylase
Alternative Symbols: NP, PUNP, PRO1837
Protein Name: purine nucleoside phosphorylase
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分子量
- 31kDa
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基因ID
- 4860
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NCBI登录号
- NP_000261
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UniProt
- P00491
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus
抗原
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