GRAP2 抗体
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北京 101111
Quick Overview for GRAP2 抗体 (ABIN509570)
抗原
See all GRAP2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-GRAP2 Purified
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特异性
- The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- GST-fusion human GRAP2/GADS protein
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亚型
- IgG2a
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anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 226-315) antibody
GRAP2 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 1G12 unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (C-Term) antibodyVerified GRAP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 1-330) antibodyGRAP2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 1-330) antibodyGRAP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 20-262) antibodyGRAP2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibody (APC)GRAP2 适用: 人 ICFC 宿主: 小鼠 Monoclonal UW40 APC
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibody (PE)GRAP2 适用: 人 ICFC 宿主: 小鼠 Monoclonal UW40 PE
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibodyGRAP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 149-251) antibodyGRAP2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 1-330) antibodyGRAP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Flow cytometry: Recommended dilution: 2-6 μg/mL. Intracellular staining.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "The Gads (GrpL) adaptor protein regulates T cell homeostasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 3, pp. 1711-20, (2004) (PubMed).
: "CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 12, pp. 6789-93, (2001) (PubMed).
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: "The Gads (GrpL) adaptor protein regulates T cell homeostasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 3, pp. 1711-20, (2004) (PubMed).
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- GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
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别名
- GRAP2
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背景
- GRB2 related adaptor protein 2,GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.,GADS, GRID, GRAP-2, GrbX
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基因ID
- 9402
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UniProt
- O75791
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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