LDLR 抗体 (AA 500-550)
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Quick Overview for LDLR 抗体 (AA 500-550) (ABIN504726)
抗原
See all LDLR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 500-550
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交叉反应
- 人, 小鼠, 灵长类
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纯化方法
- affinity purified
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免疫原
- Synthetic peptide made to an internal portion of the human protein (within AA 500-550). [Swiss-Prot# P01130]
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- -20 °C
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- LDLR (Low Density Lipoprotein Receptor (LDLR))
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别名
- LDL Receptor
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背景
- The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells
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UniProt
- P01130
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途径
- Hepatitis C, Lipid Metabolism
抗原
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