TXNIP 抗体 (AA 50-300)
Quick Overview for TXNIP 抗体 (AA 50-300) (ABIN5027615)
抗原
See all TXNIP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 50-300
-
纯化方法
- Protein A Chromatography
-
免疫原
- A partial length recombinant TxNIP protein (amino acids 50-300) was used as the immunogen for this antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1-3 μg/mL
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS containing 0.05 % BSA, PH 7.4
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
-
-
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
-
别名
- TxNIP/VDUP1
-
背景
- TXNIP (thioredoxin interacting protein) inhibits thioredoxin activity by limiting its bioavailability in response to oxidative stress. TXNIP restores COPS5-induced suppression of CDKN1B stability by interacting with COPS5 and blocks the COPS5-mediated translocation of CDKN1B from nucleus to the cytoplasm. TXNIP functions as a transcriptional repressor. TXNIP has been reported to be a suppressor of tumor cell growth and inhibits the proteasomal degradation of DDIT4, contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). TXNIP is expresed in adipose tissue, adrenal cortex, adrenal gland, amniotic fluid and amygdale.
-
分子量
- 44 kDa
-
基因ID
- 10628
-
UniProt
- Q9H3M7
-
途径
- Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome
抗原
-