Bax Inhibitor 1 抗体 (AA 1-200)
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Quick Overview for Bax Inhibitor 1 抗体 (AA 1-200) (ABIN5027485)
抗原
See all Bax Inhibitor 1 (TMBIM6) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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纯化方法
- Protein G Chromatography
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免疫原
- A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.
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亚型
- IgG2b kappa
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anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibody
TMBIM6 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal 20F430 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibodyTMBIM6 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 20F565 unconjugated
anti-Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6) antibodyTMBIM6 适用: 人 WB 宿主: 小鼠 Monoclonal 20F248 unconjugated
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应用备注
- WB: 4-6 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))
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别名
- Bi-1
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背景
- Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased, however, up-regulated expression of this protein has been linked to increased cell proliferations.
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分子量
- 30 kDa
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基因ID
- 7009
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UniProt
- P55061
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途径
- Response to Water Deprivation, ER-Nucleus Signaling
抗原
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