NPM1 抗体 (AA 18-236)
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Quick Overview for NPM1 抗体 (AA 18-236) (ABIN5027406)
抗原
See all NPM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-236
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant Nucleophosmin protein (amino acids 18-236) was used as the immunogen for this antibody.
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亚型
- IgG
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应用备注
- WB: 2-4 μg/mL, IHC: 5 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
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别名
- Nucleophosmin
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背景
- Nucleophosmin (NPM1) is a multifunctional, ubiquitously expressed nucleolar phoshoprotein which shuttles continuously between the nucleus and cytoplasm and plays an important role in cell proliferation and apoptosis. This protein exerts its functions through the interaction with a multiplicity of biological partners, specifically recognizes DNA G-quadruplexes through its C-terminal region. It is mainly localized in the nucleolus and has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. Mutations at exon 12 of NPM1 gene is a hallmark of cytogenetically normal acute myeloid leukemia.
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分子量
- 37 kDa
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基因ID
- 18148
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UniProt
- Q61937
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途径
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
抗原
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