NLRP2 抗体 (AA 850-1060)
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- 抗原 See all NLRP2 抗体
- NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
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抗原表位
- AA 850-1060
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NLRP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Protein A Chromatography
- 免疫原
- A partial length recombinant NALP2 protein (amino acids 850-1060) was used as the immunogen for this antibody.
- 亚型
- IgG
- Top Product
- Discover our top product NLRP2 Primary Antibody
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anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-1062) antibody
NLRP2 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-220) antibodyNLRP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (C-Term) antibodyNLRP2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-220) antibodyNLRP2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-1062) antibodyNLRP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-846) antibodyNLRP2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (C-Term) antibodyVerified NLRP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) antibodyNLRP2 适用: 人, 小鼠, Hamster, 猴 WB, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 150-200) antibodyNLRP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 2-4 μg/mL
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS containing 0.05 % BSA, PH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- 抗原
- NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
- 别名
- NALP2 (NLRP2 产品)
- 别名
- CLR19.9 antibody, NALP2 antibody, NBS1 antibody, PAN1 antibody, PYPAF2 antibody, NLRP2 antibody, E330007A02Rik antibody, Nalp2 antibody, NLR family pyrin domain containing 2 antibody, NACHT, LRR and PYD domains-containing protein 2 antibody, NLR family pyrin domain containing 7 antibody, NLR family, pyrin domain containing 2 antibody, NLRP2 antibody, LOC100301026 antibody, LOC100387349 antibody, NLRP7 antibody, Nlrp2 antibody
- 背景
- NALP2 (also known as PAN1/PYPAF2) is a member of the NLR (NACHT-LRR) family which includes both NODs and NALPs. Alternative names for the NLR family include CATERPILLER, NOD and NOD-LRR. NLR family members are thought to be intracellular pathogen-recognition receptors (PRRs). At least fourteen NALPs have been identified in the human genome, and a common feature among NALPs 1-3, 6, and 12 is their ability to recruit the adaptor protein ASC through a homotypic PYD-PYD interaction, which in turn recruits caspase-1 through a CARD-CARD interaction. The oligomerization of NALPs is thought to bring the inflammatory caspases into close proximity leading to their activation within the inflammasome. The NALP2/3 inflammasomes contain, in addition to NALP2 or NALP3, the caspase recruitment domain (CARD)-containing protein Cardinal, ASC and caspase 1. Processing of the pro-inflammatory cytokines IL-1b and IL-18 by caspases leads to to the secretion of active cytokines and elicits a potent inflammatory response. The expression of NALP2 is upregulated in THP-1 macrophage cells by LPS and certain cytokines including interferon g and b, supporting a role for NALP2 in host-defense and inflammation. Additionally, NALP2 is expressed in several human tumor cell lines. However, the endogenous expression of NALP2 varies widely among tumor cells lines, with the highest levels found in MCF-7 and MDA-MB-435 breast cancer, Caco2 colon cancer and UACC62 melanoma cells. This antibody recognizes NALP2, human NALP2 is a 1062 amino acid protein, it is specific for NALP2 does not cross-react with related family members PAN2 or NAC.
- 分子量
- 115 kDa
- 基因ID
- 55655
- UniProt
- Q9NX02
- 途径
- Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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