MUM1 抗体 (AA 52-278)
Quick Overview for MUM1 抗体 (AA 52-278) (ABIN5027376)
抗原
See all MUM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 52-278
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant MUM1 protein (amino acids 52-278) was used as the immunogen for this antibody.
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亚型
- IgG
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anti-Melanoma Associated Antigen (Mutated) 1 (MUM1) antibody
MUM1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4G10 unconjugated
anti-Melanoma Associated Antigen (Mutated) 1 (MUM1) (AA 401-500) antibodyMUM1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Melanoma Associated Antigen (Mutated) 1 (MUM1) (AA 661-710) antibodyMUM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Melanoma Associated Antigen (Mutated) 1 (MUM1) (AA 1-711) antibodyMUM1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Melanoma Associated Antigen (Mutated) 1 (MUM1) (AA 671-699) antibodyMUM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1-2 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))
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别名
- MUM1
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背景
- MUM1 is a member of the interferon regulatory factor family of transcription factors. This protein is required at several stages of B-cell development, including in the differentiation of mature B cell into antibody-secreting plasma cells, and is also critical for Th2 and Th17 T-cell differentiation and T-cell cytotoxic function. MUM1 is normally expressed in plasma cells, melanocytes, some B cells, and activated T cells. MUM1 acts as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. MUM1 acts as a helpful marker in the differential diagnosis of AITL(Angioimmunoblastic T cell Lymphoma with HRS-like cells and cHL.
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分子量
- 78 kDa
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基因ID
- 84939
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UniProt
- Q2TAK8
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途径
- Chromatin Binding
抗原
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