MITF 抗体 (AA 150-427)
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北京 101111
Quick Overview for MITF 抗体 (AA 150-427) (ABIN5027358)
抗原
See all MITF 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 150-427
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交叉反应
- 小鼠
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纯化方法
- Protein G Chromatography
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免疫原
- A partial length recombinant MITF protein (amino acids 150-427) was used as the immunogen for this antibody.
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亚型
- IgG1 kappa
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应用备注
- WB: 2-4 μg/mL, IHC: 10 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- MITF (Microphthalmia-Associated Transcription Factor (MITF))
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别名
- MITF
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背景
- MITF (Microphthalmia-associated transcription factor) is a basic helix-loop-helix leucine zipper (bHLH-Zip) family factor, involved in lineage-specific pathway regulation of many types of cells including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. It plays a critical role in melanogenesis as a transcriptional activator of tyrosinase, TRP-1, and TRP-2. Moreover, it regulates specification, survival, and proliferation of normal melanocytes, and controls proliferation, migration and invasion of melanoma cells. MITF is the most characterized member of the MIT family, mutations of which can lead to diseases such as Melanoma, Waardenburg syndrome, and Tietz syndrome.
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分子量
- 30 kDa
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基因ID
- 4286
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UniProt
- O75030
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途径
- Chromatin Binding
抗原
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