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Importin 8 抗体 (AA 700-1000)

IPO8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5027312
发货至: 中国
  • 抗原 See all Importin 8 (IPO8) 抗体
    Importin 8 (IPO8)
    抗原表位
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 700-1000
    适用
    • 18
    • 17
    • 4
    • 2
    • 2
    • 2
    • 1
    宿主
    • 33
    • 1
    • 1
    克隆类型
    • 34
    • 1
    多克隆
    标记
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Importin 8 antibody is un-conjugated
    应用范围
    • 13
    • 13
    • 9
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    Protein A Chromatography
    免疫原
    A partial length recombinant Importin-8 protein (amino acids 700-1,000) was used as the immunogen for this antibody.
    亚型
    IgG
    Top Product
    Discover our top product IPO8 Primary Antibody
  • 应用备注
    WB: 2-4 μg/mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS containing 0.05 % BSA, PH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原
    Importin 8 (IPO8)
    别名
    Importin-8 (IPO8 产品)
    别名
    IPO8 antibody, si:ch211-116i17.1 antibody, RANBP8 antibody, 6230418K12Rik antibody, Abcc10 antibody, C130009K11Rik antibody, MRP7 antibody, OM-1 antibody, Om1 antibody, Ranbp8 antibody, importin 8 antibody, IPO8 antibody, ipo8 antibody, Ipo8 antibody
    背景
    Importin-8 is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. It acts as a nuclear protein involved in the nucleolar transport. Importin-8 is required for cytoplasmic miRNA-guided gene silencing and is involved in loading Ago complexes into a variety of different mRNA targets, affecting the nuclear localization of Ago proteins. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Importin-8 has been proposed previously as a reference gene in the human motor cortex as it showed no differences in a study with different brain regions from chronic alcoholics and control subjects and lung samples.
    分子量
    118 kDa
    基因ID
    10526
    UniProt
    O15397
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