OTUD5 抗体 (AA 300-520)
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北京 101111
Quick Overview for OTUD5 抗体 (AA 300-520) (ABIN5027170)
抗原
See all OTUD5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 300-520
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交叉反应
- 小鼠
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.
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亚型
- IgG
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anti-OTU Domain Containing 5 (OTUD5) (AA 51-183) antibody
OTUD5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 5 (OTUD5) (AA 550-600) antibodyOTUD5 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 5 (OTUD5) (AA 501-571) antibodyOTUD5 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 5 (OTUD5) (C-Term) antibodyOTUD5 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 2-4 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- OTUD5 (OTU Domain Containing 5 (OTUD5))
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别名
- DUBA
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背景
- DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
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分子量
- 62 kDa
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基因ID
- 55593
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UniProt
- Q96G74
抗原
-
