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BRD4 抗体 (AA 140-500)

This anti-BRD4 antibody is a 兔 多克隆 antibody detecting BRD4 in WB. Suitable for 人.
产品编号 ABIN5027061
发货至: 中国

Quick Overview for BRD4 抗体 (AA 140-500) (ABIN5027061)

抗原

See all BRD4 抗体
BRD4 (Bromodomain Containing 4 (BRD4))

适用

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宿主

  • 70
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克隆类型

  • 59
  • 13
  • 1
多克隆

标记

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This BRD4 antibody is un-conjugated

应用范围

  • 45
  • 37
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Western Blotting (WB)
  • 抗原表位

    • 13
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    • 1
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    AA 140-500

    纯化方法

    Protein A Chromatography

    免疫原

    A partial length recombinant BRD4 protein (amino acids 140-500) was used as the immunogen for this antibody.

    亚型

    IgG
  • 应用备注

    WB: 2-4 μg/mL This antibody detects ~80 kDa band. The size corresponds to Isoform 2 (Uniprot ID-O60885-2) of BRD4, HUNK1, the right size is ~152 kDa O60885 O60885

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    PBS containing 0.05 % BSA, PH 7.4

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原

    BRD4 (Bromodomain Containing 4 (BRD4))

    别名

    BRD4, HUNK1

    背景

    BRD4 is a member of the BET (bromo domain and extra terminal domain) family, along with BRD2, BRD3 and BRDT. BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. A chromosomal aberration involving BRD4 is found in a rare, aggressive and lethal carcinoma arising in midline organs of young people. It expressed ubiquitously and has three isoforms. Isoform B acts as a chromatin insulator in the DNA damage response pathway.

    分子量

    88 kDa

    基因ID

    23476

    UniProt

    O60885

    途径

    Chromatin Binding, SARS-CoV-2 Protein Interactome
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