PF4 抗体
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北京 101111
Quick Overview for PF4 抗体 (ABIN5026898)
抗原
See all PF4 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- IgY-antibody
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纯化方法
- Precipitation with ammoniumsulfate , dialyse and fitration
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免疫原
- raw, native protein
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亚型
- IgY
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应用备注
- Perform a chessboard titation before the first application
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, 0.1 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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- PF4 (Platelet Factor 4 (PF4))
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别名
- Platelet-factor 4
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背景
- Platelet-Factor 4 (PF4) complex is the antigen in heparin-induced thrombocytopenia (HIT), an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have also been found in patients with thrombosis with similar HIT although they have received no prior administration of heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. It is usually found in a complex with proteoglycan.
抗原
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