ZNRF2 抗体 (AbBy Fluor® 750)
Quick Overview for ZNRF2 抗体 (AbBy Fluor® 750) (ABIN5012805)
抗原
See all ZNRF2 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ZNRF2
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亚型
- IgG
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anti-Zinc and Ring Finger 2 (ZNRF2) (C-Term) antibody
ZNRF2 适用: 人, 小鼠, 大鼠, 斑马鱼 WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-Zinc and Ring Finger 2 (ZNRF2) (AA 2-36), (N-Term) antibodyZNRF2 适用: 人 WB 宿主: 兔 Polyclonal RB49907 unconjugated
anti-Zinc and Ring Finger 2 (ZNRF2) (AA 146-207) antibodyZNRF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- IF(IHC-P) 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))
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别名
- ZNRF2
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背景
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Synonyms: E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, Znrf2, ZNRF2_HUMAN.
Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.
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基因ID
- 223082
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途径
- Synaptic Membrane
抗原
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