UNC5D 抗体 (AA 112-200) (AbBy Fluor® 680)
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北京 101111
Quick Overview for UNC5D 抗体 (AA 112-200) (AbBy Fluor® 680) (ABIN5012243)
抗原
See all UNC5D 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 112-200
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预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human UNC5H4
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亚型
- IgG
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anti-Unc-5 Homolog D (UNC5D) (AA 31-130) antibody
UNC5D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-Unc-5 Homolog D (UNC5D) (AA 90-212) antibodyUNC5D 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-5 Homolog D (UNC5D) (AA 31-130) antibodyUNC5D 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- UNC5D (Unc-5 Homolog D (UNC5D))
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别名
- UNC5D/UNC5H4
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背景
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Synonyms: Netrin receptor UNC5D, Netrin receptor Unc5h4, Protein unc 5 homolog D, Unc 5 homolog 4, Unc 5 homolog D C. elegans, Unc 5 homolog D, UNC 5D, Unc5h4, FLJ16019, KIAA1777.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
抗原
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