TNIK 抗体 (pSer764) (AbBy Fluor® 680)
Quick Overview for TNIK 抗体 (pSer764) (AbBy Fluor® 680) (ABIN5011785)
抗原
See all TNIK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer764
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特异性
- Phosphorylation site corresponds to Ser735 in mouse
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Dog,Cow,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human TNIK around the phosphorylation site of Ser764
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
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别名
- TNIK
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背景
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Synonyms: TRAF2 and NCK-interacting protein kinase, TNIK, KIAA0551
Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
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基因ID
- 23043
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UniProt
- Q9UKE5
抗原
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