TGF-beta 抗体 (AA 301-350) (AbBy Fluor® 750)
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Quick Overview for TGF-beta 抗体 (AA 301-350) (AbBy Fluor® 750) (ABIN5011529)
抗原
See all TGF-beta (TGFb) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 301-350
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特异性
- This antibody will preferentially react with TGFB1, but will also detect TGFB2 (93 % ) and TGFB3 (86 %) based upon sequence similarity.
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交叉反应
- 人, 小鼠, 兔, 大鼠, 绵羊
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预测反应
- Dog,Cow,Pig,Guinea Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human TGF Beta 1
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亚型
- IgG
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anti-TGF-beta (TGFb) (AA 301-350) antibody
TGFb 适用: 人, 小鼠, 大鼠, 兔, 绵羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊, Mink, Mustelid WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal TB21 unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, 兔, 哺乳动物 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人 ELISA, FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal TB21 unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, Cow, 犬, Hamster, 猴 ELISA, Func, D, ELISA (Capture) 宿主: 小鼠 Monoclonal TGFB-510 unconjugated
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- TGF-beta (TGFb)
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别名
- TGF Beta 1+2+3
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背景
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Synonyms: CED, LAP, DPD1, TGFB, TGFbeta, Transforming growth factor beta-1, TGF-beta-1, TGFB1, TGFB2, TGFB3
Background: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
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基因ID
- 7040
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UniProt
- P01137
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途径
- EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
抗原
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