TREX2 抗体 (C-Term)
Quick Overview for TREX2 抗体 (C-Term) (ABIN501038)
抗原
See all TREX2 (Trex2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects TREX2. The antibody will not cross-react with the related protein TREX1.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- TREX2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.
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亚型
- IgG
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anti-three Prime Repair Exonuclease 2 (Trex2) (AA 156-189), (C-Term) antibody
Trex2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51322 unconjugated
anti-three Prime Repair Exonuclease 2 (Trex2) (AA 264-299), (C-Term) antibodyTrex2 适用: 人 WB 宿主: 兔 Polyclonal RB51418 unconjugated
anti-three Prime Repair Exonuclease 2 (Trex2) (AA 223-276), (C-Term) antibodyTrex2 适用: 大鼠 WB 宿主: 兔 Polyclonal RB51156 unconjugated
anti-three Prime Repair Exonuclease 2 (Trex2) (Internal Region) antibodyVerified Trex2 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))
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别名
- TREX2
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背景
- TREX2 is one of two major human 3\' to 5\' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.Synonyms: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2
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基因ID
- 11219
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UniProt
- Q9BQ50
抗原
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