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FNBP1L 抗体 (C-Term)

This anti-FNBP1L antibody is a 兔 多克隆 antibody detecting FNBP1L in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN501002
发货至: 中国

Quick Overview for FNBP1L 抗体 (C-Term) (ABIN501002)

抗原

See all FNBP1L 抗体
FNBP1L (Formin Binding Protein 1-Like (FNBP1L))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

  • 40
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多克隆

标记

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This FNBP1L antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

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    C-Term

    特异性

    This antibody detects FNBP1L at C-term.

    交叉反应 (详细)

    Species reactivity (tested):Huuman, mouse, rat

    纯化方法

    Peptide affinity chromatography

    免疫原

    TOCA-1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human TOCA-1.

    亚型

    IgG
  • 应用备注

    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    FNBP1L (Formin Binding Protein 1-Like (FNBP1L))

    别名

    FNBP1L

    背景

    Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells, its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.Synonyms: C1orf39, Formin-binding protein 1-like, TOCA1, Transducer of Cdc42-dependent actin assembly protein 1

    基因ID

    54874

    NCBI登录号

    NP_001020119
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