TMED10 抗体 (C-Term)
Quick Overview for TMED10 抗体 (C-Term) (ABIN500990)
抗原
See all TMED10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects TMED10 / TMP21 at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- TMP21 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TMP21.
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亚型
- IgG
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anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 101-200) antibody
TMED10 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (C-Term) antibodyVerified TMED10 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 143-192) antibodyTMED10 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 斑马鱼, 豚鼠, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 100-200) antibodyTMED10 适用: 人, 小鼠, 大鼠, 兔 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (Center) antibodyTMED10 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
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别名
- TMED10 / TMP21
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背景
- TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the γ- and ε-sites and can lead to the accumulation of the Aβ cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased γ-secretase activity but not ε-secretase activity, and increased Aβ production, demonstrating that TMP21 can modulate γ-secretase activity.Synonyms: 21 kDa transmembrane-trafficking protein, S31I125, Transmembrane emp24 domain-containing protein 10, Transmembrane protein Tmp21
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基因ID
- 10972
抗原
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