TMEM38B 抗体 (C-Term)
Quick Overview for TMEM38B 抗体 (C-Term) (ABIN500986)
抗原
See all TMEM38B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- TMEM38B antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38B.
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亚型
- IgG
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anti-Transmembrane Protein 38B (TMEM38B) (AA 249-291) antibody
TMEM38B 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38B (TMEM38B) (AA 116-126), (Intracellular) antibodyTMEM38B 适用: 大鼠 WB, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38B (TMEM38B) (C-Term) antibodyTMEM38B 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- TMEM38B (Transmembrane Protein 38B (TMEM38B))
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别名
- TMEM38B
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背景
- TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.Synonyms: C9orf87, TRIC-B, TRICB, Transmembrane protein 38B, Trimeric intracellular cation channel type B
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基因ID
- 55151
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NCBI登录号
- NP_060582
抗原
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