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ANO1 抗体 (N-Term)

ANO1 适用: 人, 小鼠 IF, WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN500970
发货至: 中国
  • 抗原 See all ANO1 抗体
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    抗原表位
    • 18
    • 15
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 127
    • 30
    • 29
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 81
    • 50
    克隆类型
    • 67
    • 64
    多克隆
    标记
    • 57
    • 13
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ANO1 antibody is un-conjugated
    应用范围
    • 62
    • 51
    • 43
    • 37
    • 35
    • 20
    • 18
    • 13
    • 13
    • 9
    • 4
    • 3
    • 2
    • 1
    Immunofluorescence (IF), Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    At least three isoforms are known to exist. This antibody will not cross-react with TMEM16B.
    交叉反应 (详细)
    Species reactivity (tested):Human, Mouse.
    纯化方法
    Peptide affinity chromatography
    免疫原
    17 amino acid peptide from near the amino terminus of Human TMEM16A
    亚型
    IgG
    Top Product
    Discover our top product ANO1 Primary Antibody
  • 应用备注
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 0.02 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    别名
    ANO1 / DOG1 (ANO1 产品)
    别名
    DOG1 antibody, ORAOV2 antibody, TAOS2 antibody, TMEM16A antibody, Tmem16a antibody, anoctamin 1 antibody, anoctamin 1, calcium activated chloride channel antibody, Ano1 antibody, ANO1 antibody
    背景
    Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle, mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.Synonyms: Anoctamin-1, DOG-1, Discovered on gastrointestinal stromal tumors protein 1, ORAOV2, Oral cancer overexpressed protein 2, TAOS2, TMEM16A, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2
    基因ID
    55107
    NCBI登录号
    NP_060513
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