TIGAR 抗体 (Center)
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北京 101111
Quick Overview for TIGAR 抗体 (Center) (ABIN500907)
抗原
See all TIGAR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects TIGAR at center.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- TIGAR antibody was raised against a 18 amino acid peptide from near the center of human TIGAR.
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亚型
- IgG
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anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 24-188) antibody
TIGAR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 161-270) antibodyTIGAR 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 220-270) antibodyTIGAR 适用: 人 IHC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-TP53 induced glycolysis regulatory phosphatase (TIGAR) (AA 1-270) antibodyTIGAR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
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别名
- TIGAR
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背景
- The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.Synonyms: 6-bisphosphatase TIGAR, C12orf5, Probable fructose-2, TP53-induced glycolysis and apoptosis regulator
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基因ID
- 57103
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NCBI登录号
- NP_065108
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途径
- Warburg Effect
抗原
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