THEM4 抗体 (Center)
This anti-THEM4 antibody is a 兔 多克隆 antibody detecting THEM4 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for THEM4 抗体 (Center) (ABIN500905)
抗原
See all THEM4 抗体
THEM4
(Thioesterase Superfamily Member 4 (THEM4))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This THEM4 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- Center
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特异性
- This antibody detects THEM4 / CTMP.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chropmatography
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免疫原
- THEM4 antibody was raised against an 18 amino acid peptide near the center of human THEM4.
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亚型
- IgG
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anti-Thioesterase Superfamily Member 4 (THEM4) (AA 1-240) antibody
THEM4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Thioesterase Superfamily Member 4 (THEM4) (AA 37-150) antibodyTHEM4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- THEM4 (Thioesterase Superfamily Member 4 (THEM4))
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别名
- THEM4 / CTMP
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背景
- THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program. The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.Synonyms: Carboxyl-terminal modulator protein, Thioesterase superfamily member 4
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基因ID
- 117145
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NCBI登录号
- NP_444283
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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