GPR124 抗体 (C-Term)
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北京 101111
Quick Overview for GPR124 抗体 (C-Term) (ABIN500895)
抗原
See all GPR124 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects GPR124 / TEM5 at C-term.
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交叉反应 (详细)
- Species reactivity (tested):Human, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- TEM5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human TEM5.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- GPR124 (G Protein-Coupled Receptor 124 (GPR124))
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别名
- GPR124 / TEM5
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背景
- Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.Synonyms: G-protein coupled receptor 124, KIAA1531, Tumor endothelial marker 5
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基因ID
- 25960
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UniProt
- Q96PE1
抗原
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