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SYPL2 抗体 (C-Term)

This anti-SYPL2 antibody is a 兔 多克隆 antibody detecting SYPL2 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN500857
发货至: 中国

Quick Overview for SYPL2 抗体 (C-Term) (ABIN500857)

抗原

See all SYPL2 抗体
SYPL2 (Synaptophysin-Like 2 (SYPL2))

适用

人, 小鼠, 大鼠

宿主

  • 1

克隆类型

  • 1
多克隆

标记

  • 1
This SYPL2 antibody is un-conjugated

应用范围

  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

    C-Term

    特异性

    This antibody detects SYPL2. It will not cross-react with SYPL1.

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse, rat

    纯化方法

    Peptide affinity chromatography

    免疫原

    SYPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.

    亚型

    IgG
  • 应用备注

    ELISA. Western blot. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    SYPL2 (Synaptophysin-Like 2 (SYPL2))

    别名

    SYPL2

    背景

    SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist.Synonyms: Synaptophysin-like protein 2

    基因ID

    284612

    NCBI登录号

    NP_001035799
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