SYPL2 抗体 (C-Term)
This anti-SYPL2 antibody is a 兔 多克隆 antibody detecting SYPL2 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for SYPL2 抗体 (C-Term) (ABIN500857)
抗原
See all SYPL2 抗体
SYPL2
(Synaptophysin-Like 2 (SYPL2))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This SYPL2 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- C-Term
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特异性
- This antibody detects SYPL2. It will not cross-react with SYPL1.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- SYPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.
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亚型
- IgG
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应用备注
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ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- SYPL2 (Synaptophysin-Like 2 (SYPL2))
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别名
- SYPL2
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背景
- SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist.Synonyms: Synaptophysin-like protein 2
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基因ID
- 284612
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NCBI登录号
- NP_001035799
抗原
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