SLITRK1 抗体 (C-Term)
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Quick Overview for SLITRK1 抗体 (C-Term) (ABIN500750)
抗原
See all SLITRK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects SLITRK1 at C-term. It is predicted to have no cross-reactivity to other Slitrk proteins.
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交叉反应 (详细)
- Species reactivity (tested):Huamn, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- Slitrk1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Slitrk1.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))
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别名
- SLITRK1
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背景
- SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.Synonyms: KIAA1910, LRRC12, Leucine-rich repeat-containing protein 12, SLIT and NTRK-like protein 1
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基因ID
- 114798
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NCBI登录号
- NP_443142
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UniProt
- Q96PX8
抗原
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