PPP1R9A 抗体 (AA 115-165) (AbBy Fluor® 750)
Quick Overview for PPP1R9A 抗体 (AA 115-165) (AbBy Fluor® 750) (ABIN5007456)
抗原
See all PPP1R9A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 115-165
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Dog,Cow,Sheep,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Neurabin 1
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亚型
- IgG
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anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A) (AA 1-243) antibody
PPP1R9A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A) (AA 1090-1188) antibodyPPP1R9A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6A10 unconjugated
anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A) (C-Term) antibodyPPP1R9A 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A) (N-Term) antibodyPPP1R9A 适用: 人, 小鼠, Cow, 犬, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A) (C-Term) antibodyPPP1R9A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A) (N-Term) antibodyPPP1R9A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- PPP1R9A (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A))
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别名
- Neurabin 1/PPP1R9A
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背景
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Synonyms: FLJ20068, KIAA1222, NEB1_HUMAN, Neurabin I, Neurabin-1, Neurabin-I, Neurabin1, Neurabin-1, NeurabinI, Neurabin1, Neural tissue specic F actin binding protein I, Neural tissue-specic F-actin-binding protein I, NRB 1, NRB I, NRB1, NRBI, PPP1R9A, Protein phosphatase 1 regulatory inhibitor subunit 9A, Protein phosphatase 1 regulatory subunit 9A.
Background: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons, it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence, mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).
抗原
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