SIPA1L1 抗体 (N-Term)
This anti-SIPA1L1 antibody is a 兔 多克隆 antibody detecting SIPA1L1 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
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Quick Overview for SIPA1L1 抗体 (N-Term) (ABIN500716)
抗原
See all SIPA1L1 抗体
SIPA1L1
(Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This SIPA1L1 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- SIPA1L1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human SIPA1L1.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))
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别名
- SIPA1L1
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背景
- Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.Synonyms: E6-targeted protein 1, E6TP1, KIAA0440, SIPA1-like protein 1, Signal-induced proliferation-associated 1-like protein 1
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基因ID
- 26037
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NCBI登录号
- NP_056371
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UniProt
- O43166
抗原
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