RNASEH2A 抗体 (Center)
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- 抗原 See all RNASEH2A 抗体
- RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
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抗原表位
- Center
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RNASEH2A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- This antibody detects RNAse H2A.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- Peptide affinity chromatography
- 免疫原
- RNAse H2A antibody was raised against a 17 amino acid peptide near the center of human RNAse H2A.
- 亚型
- IgG
- Top Product
- Discover our top product RNASEH2A Primary Antibody
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anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibody
RNASEH2A 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3G5-F5 unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-301) antibodyRNASEH2A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人, 斑马鱼, Cow, 马, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (Middle Region) antibodyRNASEH2A 适用: 人, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-301) antibodyRNASEH2A 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to 3 months, and at -20 °C thereafter.
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: "CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." in: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).
: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." in: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).
: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).
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: "CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." in: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).
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- 抗原
- RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
- 别名
- RNASEH2A (RNASEH2A 产品)
- 背景
- Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits, all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.Synonyms: AGS4, Aicardi-Goutieres syndrome 4 protein, RNASEHI, RNAse H2A, RNHIA, RNase H2 subunit A, RNase HI large subunit, Ribonuclease H2 subunit A, Ribonuclease HI large subunit, Ribonuclease HI subunit A
- 基因ID
- 10535
- UniProt
- O75792
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