TP53AIP1 抗体 (N-Term)
(1 reference)Quick Overview for TP53AIP1 抗体 (N-Term) (ABIN500433)
抗原
See all TP53AIP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody dreacts to p53AIP1. It will detect all three isoforms.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Peptide affinity chromatograpy
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免疫原
- p53AIP1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.
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亚型
- IgG
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anti-P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1) (AA 65-124) antibody
TP53AIP1 适用: 人, 小鼠 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1) (AA 1-108) antibodyTP53AIP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1) (AA 1-108) antibodyTP53AIP1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1) (N-Term) antibodyTP53AIP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1) (AA 1-108) antibodyTP53AIP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1) (AA 75-124) antibodyTP53AIP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 4 - 8 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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: "ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53." in: Oncogene, Vol. 34, Issue 49, pp. 5983-96, (2016) (PubMed).
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: "ELAS1-mediated inhibition of the cyclin G1-B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53." in: Oncogene, Vol. 34, Issue 49, pp. 5983-96, (2016) (PubMed).
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- TP53AIP1 (P53-Regulated Apoptosis-Inducing Protein 1 (TP53AIP1))
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别名
- TP53AIP1
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背景
- The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to existSynonyms: p53-regulated apoptosis-inducing protein 1, p53AIP1
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基因ID
- 63970
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UniProt
- Q9HCN2
抗原
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