NOTUM 抗体 (N-Term)
This 兔 多克隆 anti-NOTUM antibody specifically detects NOTUM in WB, IHC (p) 和 EIA. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN500375
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for NOTUM 抗体 (N-Term) (ABIN500375)
抗原
See all NOTUM 抗体
NOTUM
(Notum Pectinacetylesterase Homolog (NOTUM))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This NOTUM antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
-
-
抗原表位
- N-Term
-
特异性
- This antibody detects Notum.
-
交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Rat.
-
纯化方法
- Peptide Affinity Chromatography
-
免疫原
- NOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of Human NOTUM.
-
亚型
- IgG
-
-
anti-Notum Pectinacetylesterase Homolog (NOTUM) (AA 100-235) antibody
NOTUM 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- PBS containing 0.02 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
-
别名
- Notum
-
背景
- In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by b-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
-
基因ID
- 147111
-
NCBI登录号
- NP_848588
-
UniProt
- Q6P988
抗原
-
You are here:
