Reticulon 4 抗体 (Isoform 1)
Quick Overview for Reticulon 4 抗体 (Isoform 1) (ABIN500369)
抗原
See all Reticulon 4 (RTN4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Isoform 1
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特异性
- This antibody detects RTN4 / NOGO at Center. It is specific for NogoA and NogoE.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- NogoA antibody was raised against a 19 amino acid peptide from near the center of human NogoA.
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亚型
- IgG
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anti-Reticulon 4 (RTN4) (AA 501-515) antibody
RTN4 适用: 人, 猴 IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (AA 14-30) antibodyRTN4 适用: 人, 小鼠, 大鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (AA 301-400) antibodyRTN4 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (AA 251-357) antibodyRTN4 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (AA 28-58) antibodyRTN4 适用: 人 WB 宿主: 兔 Polyclonal RB54371 unconjugated
anti-Reticulon 4 (RTN4) (AA 81-130) antibodyRTN4 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 绵羊, 猴, 马, 豚鼠, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (AA 254-303) antibodyRTN4 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 绵羊, 猴, 马, Pig, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (Center) antibodyRTN4 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 绵羊, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 (RTN4) (Middle Region) antibodyRTN4 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 绵羊, 马, 豚鼠, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Reticulon 4 (RTN4)
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别名
- Reticulon-4 / RTN4
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背景
- NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients. Despite its predicted molecular weight, NogoA typically migrates at 180 kDa in an SDS-PAGE. At least five isoforms of Nogo are known to exist.Synonyms: Foocen, KIAA0886, NOGO, NSP, Neurite outgrowth inhibitor, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, Reticulon-5
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基因ID
- 57142
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NCBI登录号
- NP_065393
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UniProt
- Q9NQC3
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途径
- Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome
抗原
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