TACR3 抗体 (Center)
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Quick Overview for TACR3 抗体 (Center) (ABIN500361)
抗原
See all TACR3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects Tachykinin receptor 3 (TACR3) at center. It does not recognize NK1R or NK2R.
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse
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纯化方法
- Peptide affinity chromatography
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免疫原
- NK3R antibody was raised against a 18 amino acid peptide from near the center of human NK3R.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- TACR3 (Tachykinin Receptor 3 (TACR3))
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背景
- The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.Synonyms: NK-3 receptor, NK-3R, NK3R, NKR, Neurokinin B receptor, Neuromedin-K receptor, TAC3R
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基因ID
- 6870
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NCBI登录号
- NP_001050
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UniProt
- P29371
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途径
- Feeding Behaviour
抗原
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