NRN1 抗体 (Center)
Quick Overview for NRN1 抗体 (Center) (ABIN500332)
抗原
See all NRN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects Neuritin.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Peptide affinity chromatography
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免疫原
- Neuritin antibody was raised against a 20 amino acid peptide from near the center of human neuritin.
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亚型
- IgG
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anti-Neuritin 1 (NRN1) (AA 51-142) antibody
NRN1 适用: 人, 小鼠, 大鼠 ELISA, WB, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuritin 1 (NRN1) (AA 28-142) antibodyNRN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuritin 1 (NRN1) (AA 28-116) antibodyNRN1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- NRN1 (Neuritin 1 (NRN1))
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别名
- Neuritin
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背景
- As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.Synonyms: NRN, NRN1
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基因ID
- 51299
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NCBI登录号
- NP_057672
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UniProt
- Q9NPD7
抗原
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