MTBP 抗体 (Middle Region)
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北京 101111
Quick Overview for MTBP 抗体 (Middle Region) (ABIN500294)
抗原
See all MTBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 122-139, Middle Region
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特异性
- This antibody detects MTBP at center.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Peptide affinity chromatography
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免疫原
- MTBP antibody was raised against a synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids (7).
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亚型
- IgG
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anti-MDM2 Binding Protein (MTBP) (AA 853-881), (C-Term) antibody
MTBP 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20020 unconjugated
anti-MDM2 Binding Protein (MTBP) antibodyMTBP 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-MDM2 Binding Protein (MTBP) (AA 567-724) antibodyMTBP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MDM2 Binding Protein (MTBP) (AA 23-350) antibodyMTBP 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MDM2 Binding Protein (MTBP) (AA 122-139) antibodyMTBP 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- MTBP (MDM2 Binding Protein (MTBP))
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别名
- MTBP
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背景
- The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6) and MTBP (7), were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53 (7). MTBP is expressed in a variety of normal tissues (7).Synonyms: Mdm2, Mdm2-binding protein, hMTBP
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基因ID
- 27085
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NCBI登录号
- NP_071328
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UniProt
- Q96DY7
抗原
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