IFIH1 抗体 (Center)
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北京 101111
Quick Overview for IFIH1 抗体 (Center) (ABIN500266)
抗原
See all IFIH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects Helicard at Center.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse
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纯化方法
- Peptide Affinity Chromatography
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免疫原
- 16 amino acid peptide from near the center of Human MDA5.
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亚型
- IgG
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anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 1-205) antibody
IFIH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (N-Term) antibodyVerified IFIH1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (C-Term) antibodyIFIH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (C-Term) antibodyIFIH1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 700-1025) antibodyIFIH1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) antibodyIFIH1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 612-661) antibodyIFIH1 适用: 人, 小鼠, 大鼠, Cow, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) antibodyKD Validated IFIH1 适用: 人 WB 宿主: 兔 Monoclonal 24GB6085 unconjugated Recombinant Antibody
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 1-221) antibodyIFIH1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (AA 928-1023) antibodyIFIH1 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F6 unconjugated
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))
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别名
- Helicard
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背景
- The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kB. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.Synonyms: Helicase with 2 CARD domains, IFIH1, Interferon-induced helicase C domain-containing protein 1, MDA5, Melanoma differentiation-associated protein 5, Murabutide down-regulated protein, RH116, RNA helicase-DEAD box protein 116
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基因ID
- 64135
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NCBI登录号
- NP_071451
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UniProt
- Q9BYX4
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途径
- Activation of Innate immune Response
抗原
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